Embeddings from deep learning transfer GO annotations beyond homology

Abstract Knowing protein function is crucial to advance molecular and medical biology, yet experimental function annotations through the Gene Ontology (GO) exist for fewer than 0.5% of all known proteins. Computational methods bridge this sequence-annotation gap typically through homology-based anno...

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Autores principales: Maria Littmann, Michael Heinzinger, Christian Dallago, Tobias Olenyi, Burkhard Rost
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/30047864d85f4054b8b99879adff217c
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