Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer

Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer

Abstract The colony stimulating factor 2 receptor subunit beta (CSF2RB) is the common signaling subunit of the cytokine receptors for IL‐3, IL‐5, and GM‐CSF. Several studies have shown that spontaneous and random mutants of CSF2RB can lead to ligand independence in vitro. To date, no report(s) have...

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Main Authors: Mamoon Rashid, Rizwan Ali, Bader Almuzzaini, Hao Song, Alshaimaa AlHallaj, Al Abdulrahman Abdulkarim, Omar Mohamed Baz, Hajar Al Zahrani, Muhammed Mustafa Sabeena, Wardah Alharbi, Mohamed Hussein, Mohamed Boudjelal
Format: article
Language:EN
Published: Wiley 2021
Subjects:
breast cancer
breast cancer cell line
CSF2RB‐activating mutation
cytokine receptor
hβc receptor
JAK2 inhibitor
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/301f3883e51a43d9bf7f977108cd73df
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https://doaj.org/article/301f3883e51a43d9bf7f977108cd73df

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