A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodomic profiling, they identify HIF-2α- HILPDA axis pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:30381869b6f34533b2be4a86cf0a583a
record_format	dspace
spelling	oai:doaj.org-article:30381869b6f34533b2be4a86cf0a583a2021-12-02T16:51:00ZA GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis10.1038/s41467-019-09277-92041-1723https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09277-9https://doaj.org/toc/2041-1723Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodomic profiling, they identify HIF-2α- HILPDA axis promotes ferroptosis via enrichment of PUFA lipids.Yilong ZouMichael J. PalteAmy A. DeikHaoxin LiJohn K. EatonWenyu WangYuen-Yi TsengRebecca DeasyMaria Kost-AlimovaVlado DančíkElizaveta S. LeshchinerVasanthi S. ViswanathanSabina SignorettiToni K. ChoueiriJesse S. BoehmBridget K. WagnerJohn G. DoenchClary B. ClishPaul A. ClemonsStuart L. SchreiberNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yilong Zou Michael J. Palte Amy A. Deik Haoxin Li John K. Eaton Wenyu Wang Yuen-Yi Tseng Rebecca Deasy Maria Kost-Alimova Vlado Dančík Elizaveta S. Leshchiner Vasanthi S. Viswanathan Sabina Signoretti Toni K. Choueiri Jesse S. Boehm Bridget K. Wagner John G. Doench Clary B. Clish Paul A. Clemons Stuart L. Schreiber A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
description	Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodomic profiling, they identify HIF-2α- HILPDA axis promotes ferroptosis via enrichment of PUFA lipids.
format	article
author	Yilong Zou Michael J. Palte Amy A. Deik Haoxin Li John K. Eaton Wenyu Wang Yuen-Yi Tseng Rebecca Deasy Maria Kost-Alimova Vlado Dančík Elizaveta S. Leshchiner Vasanthi S. Viswanathan Sabina Signoretti Toni K. Choueiri Jesse S. Boehm Bridget K. Wagner John G. Doench Clary B. Clish Paul A. Clemons Stuart L. Schreiber
author_facet	Yilong Zou Michael J. Palte Amy A. Deik Haoxin Li John K. Eaton Wenyu Wang Yuen-Yi Tseng Rebecca Deasy Maria Kost-Alimova Vlado Dančík Elizaveta S. Leshchiner Vasanthi S. Viswanathan Sabina Signoretti Toni K. Choueiri Jesse S. Boehm Bridget K. Wagner John G. Doench Clary B. Clish Paul A. Clemons Stuart L. Schreiber
author_sort	Yilong Zou
title	A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
title_short	A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
title_full	A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
title_fullStr	A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
title_full_unstemmed	A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
title_sort	gpx4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a
work_keys_str_mv	AT yilongzou agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT michaeljpalte agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT amyadeik agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT haoxinli agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT johnkeaton agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT wenyuwang agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT yuenyitseng agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT rebeccadeasy agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT mariakostalimova agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT vladodancik agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT elizavetasleshchiner agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT vasanthisviswanathan agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT sabinasignoretti agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT tonikchoueiri agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT jessesboehm agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT bridgetkwagner agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT johngdoench agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT clarybclish agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT paulaclemons agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT stuartlschreiber agpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT yilongzou gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT michaeljpalte gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT amyadeik gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT haoxinli gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT johnkeaton gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT wenyuwang gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT yuenyitseng gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT rebeccadeasy gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT mariakostalimova gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT vladodancik gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT elizavetasleshchiner gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT vasanthisviswanathan gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT sabinasignoretti gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT tonikchoueiri gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT jessesboehm gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT bridgetkwagner gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT johngdoench gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT clarybclish gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT paulaclemons gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis AT stuartlschreiber gpx4dependentcancercellstateunderliestheclearcellmorphologyandconferssensitivitytoferroptosis
_version_	1718382968332877824

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Ejemplares similares