Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators

Abstract Human GLUT5 is a fructose-specific transporter in the glucose transporter family (GLUT, SLC2 gene family). Its substrate-specificity and tissue-specific expression make it a promising target for treatment of diabetes, metabolic syndrome and cancer, but few GLUT5 inhibitors are known. To ide...

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Autores principales: Joanna Tripp, Christine Essl, Cristina V. Iancu, Eckhard Boles, Jun-yong Choe, Mislav Oreb
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/304ac976992841c9828f6fc9c777528f
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