Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

Abstract The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate exc...

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Autores principales: Yurie Ogura, Ryoji Kaneko, Kota Ujibe, Yuma Wakamatsu, Hiromi Hirata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/30639de4a8f842e2b62a9076057aba0f
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