Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

Abstract The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate exc...

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Autores principales:	Yurie Ogura, Ryoji Kaneko, Kota Ujibe, Yuma Wakamatsu, Hiromi Hirata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30639de4a8f842e2b62a9076057aba0f
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spelling	oai:doaj.org-article:30639de4a8f842e2b62a9076057aba0f2021-12-02T16:17:34ZLoss of αklotho causes reduced motor ability and short lifespan in zebrafish10.1038/s41598-021-93909-y2045-2322https://doaj.org/article/30639de4a8f842e2b62a9076057aba0f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93909-yhttps://doaj.org/toc/2045-2322Abstract The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate excretion. Interestingly, αKlotho knockout mice show an accelerated aging and a shortened life span. Similarly, C. elegans lacking the αklotho homologue showed a short life span. However, the physiological basis of aging-related function of αklotho remain unclear. The αklotho-deficient vertebrate animals other than mice have been awaited as an alternative model of premature aging. We here employed zebrafish in our study and revealed that αklotho mutant zebrafish appeared to be normal at 3 months postfertilization (mpf) but eventually underwent premature death by 9 mpf, while normal zebrafish is known to survive for 42 months. We also assessed the motor ability of zebrafish in a forced swimming assay and found that αklotho mutant zebrafish displayed reduced swimming performance before their survival declined. A recent study also reported a similar finding that αklotho-deficient zebrafish exhibited a short life span and reduced spontaneous movements. Taken together, these results suggest that αKlotho mutant zebrafish show premature aging and are useful to investigate aging in vertebrates.Yurie OguraRyoji KanekoKota UjibeYuma WakamatsuHiromi HirataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yurie Ogura Ryoji Kaneko Kota Ujibe Yuma Wakamatsu Hiromi Hirata Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
description	Abstract The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate excretion. Interestingly, αKlotho knockout mice show an accelerated aging and a shortened life span. Similarly, C. elegans lacking the αklotho homologue showed a short life span. However, the physiological basis of aging-related function of αklotho remain unclear. The αklotho-deficient vertebrate animals other than mice have been awaited as an alternative model of premature aging. We here employed zebrafish in our study and revealed that αklotho mutant zebrafish appeared to be normal at 3 months postfertilization (mpf) but eventually underwent premature death by 9 mpf, while normal zebrafish is known to survive for 42 months. We also assessed the motor ability of zebrafish in a forced swimming assay and found that αklotho mutant zebrafish displayed reduced swimming performance before their survival declined. A recent study also reported a similar finding that αklotho-deficient zebrafish exhibited a short life span and reduced spontaneous movements. Taken together, these results suggest that αKlotho mutant zebrafish show premature aging and are useful to investigate aging in vertebrates.
format	article
author	Yurie Ogura Ryoji Kaneko Kota Ujibe Yuma Wakamatsu Hiromi Hirata
author_facet	Yurie Ogura Ryoji Kaneko Kota Ujibe Yuma Wakamatsu Hiromi Hirata
author_sort	Yurie Ogura
title	Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
title_short	Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
title_full	Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
title_fullStr	Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
title_full_unstemmed	Loss of αklotho causes reduced motor ability and short lifespan in zebrafish
title_sort	loss of αklotho causes reduced motor ability and short lifespan in zebrafish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30639de4a8f842e2b62a9076057aba0f
work_keys_str_mv	AT yurieogura lossofaklothocausesreducedmotorabilityandshortlifespaninzebrafish AT ryojikaneko lossofaklothocausesreducedmotorabilityandshortlifespaninzebrafish AT kotaujibe lossofaklothocausesreducedmotorabilityandshortlifespaninzebrafish AT yumawakamatsu lossofaklothocausesreducedmotorabilityandshortlifespaninzebrafish AT hiromihirata lossofaklothocausesreducedmotorabilityandshortlifespaninzebrafish
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Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

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