PMS1077 sensitizes TNF-α induced apoptosis in human prostate cancer cells by blocking NF-κB signaling pathway.

PMS1077 sensitizes TNF-α induced apoptosis in human prostate cancer cells by blocking NF-κB signaling pathway.

Our previous studies have demonstrated that PMS1077, a platelet-activating factor (PAF) antagonist, could induce apoptosis of Raji cells. However, the mechanism of action has not yet been determined. The nuclear transcription factor-kappa B (NF-κB) signaling pathway plays a critical role in tumor ce...

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Autores principales: Jie Shi, Jing Chen, Nawal Serradji, Ximing Xu, Heng Zhou, Yinxing Ma, Zhihong Sun, Peng Jiang, Yuping Du, Jinbo Yang, Changzhi Dong, Qin Wang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/306cbc1f5ff04cafa91aa34ffbe4b048
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https://doaj.org/article/306cbc1f5ff04cafa91aa34ffbe4b048

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