Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets
The analysis of essential genes in pathogens can be used to discover potential antimicrobial targets. Here, the authors use a machine learning model and chemogenomic analyses to generate genome-wide gene essentiality predictions for the fungal pathogen Candida albicans, define the function of three...
Enregistré dans:
Auteurs principaux: | Ci Fu, Xiang Zhang, Amanda O. Veri, Kali R. Iyer, Emma Lash, Alice Xue, Huijuan Yan, Nicole M. Revie, Cassandra Wong, Zhen-Yuan Lin, Elizabeth J. Polvi, Sean D. Liston, Benjamin VanderSluis, Jing Hou, Yoko Yashiroda, Anne-Claude Gingras, Charles Boone, Teresa R. O’Meara, Matthew J. O’Meara, Suzanne Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/30b53e35a0bc440e930c93cb62d5cbf8 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Staurosporine Induces Filamentation in the Human Fungal Pathogen <named-content content-type="genus-species">Candida albicans</named-content> via Signaling through Cyr1 and Protein Kinase A
par: Jinglin L. Xie, et autres
Publié: (2017) -
mSphere of Influence: Start with an Interesting Biological Phenomenon
par: Teresa O’Meara
Publié: (2019) -
Effect of health systems context on infant and child mortality in sub-Saharan Africa from 1995 to 2015, a longitudinal cohort analysis
par: Ryan A. Simmons, et autres
Publié: (2021) -
High-Throughput Screening Identifies Genes Required for <italic toggle="yes">Candida albicans</italic> Induction of Macrophage Pyroptosis
par: Teresa R. O’Meara, et autres
Publié: (2018) -
Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria
par: Jessica Y. El Khoury, et autres
Publié: (2019)