Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures

During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological data, provide a comprehensive view of RdRP trans...

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Autores principales:	Meihua Wang, Rui Li, Bo Shu, Xuping Jing, Han-Qing Ye, Peng Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30bdaf61e4394908a7fdee800bf4c089
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spelling	oai:doaj.org-article:30bdaf61e4394908a7fdee800bf4c0892021-12-02T15:49:34ZStringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures10.1038/s41467-020-16234-42041-1723https://doaj.org/article/30bdaf61e4394908a7fdee800bf4c0892020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16234-4https://doaj.org/toc/2041-1723During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological data, provide a comprehensive view of RdRP translocation.Meihua WangRui LiBo ShuXuping JingHan-Qing YePeng GongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meihua Wang Rui Li Bo Shu Xuping Jing Han-Qing Ye Peng Gong Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
description	During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological data, provide a comprehensive view of RdRP translocation.
format	article
author	Meihua Wang Rui Li Bo Shu Xuping Jing Han-Qing Ye Peng Gong
author_facet	Meihua Wang Rui Li Bo Shu Xuping Jing Han-Qing Ye Peng Gong
author_sort	Meihua Wang
title	Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
title_short	Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
title_full	Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
title_fullStr	Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
title_full_unstemmed	Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
title_sort	stringent control of the rna-dependent rna polymerase translocation revealed by multiple intermediate structures
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30bdaf61e4394908a7fdee800bf4c089
work_keys_str_mv	AT meihuawang stringentcontrolofthernadependentrnapolymerasetranslocationrevealedbymultipleintermediatestructures AT ruili stringentcontrolofthernadependentrnapolymerasetranslocationrevealedbymultipleintermediatestructures AT boshu stringentcontrolofthernadependentrnapolymerasetranslocationrevealedbymultipleintermediatestructures AT xupingjing stringentcontrolofthernadependentrnapolymerasetranslocationrevealedbymultipleintermediatestructures AT hanqingye stringentcontrolofthernadependentrnapolymerasetranslocationrevealedbymultipleintermediatestructures AT penggong stringentcontrolofthernadependentrnapolymerasetranslocationrevealedbymultipleintermediatestructures
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Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures

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