RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs)

RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs)

Background: We have previously shown that overexpression of RANK-c in ER-negative breast cancer cell lines attenuates aggressive properties of cancer cells, partially through a RANK-c/EGFR interaction. EGFR inhibition through TKIs in breast cancer has been tested in triple-negative disease settings...

Full description

Saved in:
Bibliographic Details
Main Authors: Chaido Sirinian, Anastasios D. Papanastasiou, Soren E. Degn, Theodora Frantzi, Christos Aronis, Dimitrios Chaniotis, Thomas Makatsoris, Angelos Koutras, Haralabos P. Kalofonos
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
breast cancer
ER-negative
EGFR
TKIs
RANK-c
Genetics
QH426-470
Online Access:https://doaj.org/article/30d05a3f504f497184a3252e2af9cfdd
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/30d05a3f504f497184a3252e2af9cfdd

Similar Items