In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function

Despite the known role of midbrain dopaminergic (mDA) signaling in the homeostatic control of mood and motor functions, little is known about how gene expression in these neurons is regulated. Here, authors develop an in vivo nuclear tagging and capture technique for low-input chromatin accessibilit...

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Autores principales:	Luis M. Tuesta, Mohamed N. Djekidel, Renchao Chen, Falong Lu, Wengang Wang, Bernardo L. Sabatini, Yi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30e693ae83634bd09940961f8cef6c42
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spelling	oai:doaj.org-article:30e693ae83634bd09940961f8cef6c422021-12-02T16:57:40ZIn vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function10.1038/s41467-019-10267-02041-1723https://doaj.org/article/30e693ae83634bd09940961f8cef6c422019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10267-0https://doaj.org/toc/2041-1723Despite the known role of midbrain dopaminergic (mDA) signaling in the homeostatic control of mood and motor functions, little is known about how gene expression in these neurons is regulated. Here, authors develop an in vivo nuclear tagging and capture technique for low-input chromatin accessibility and transcriptome profiling of genetically-defined neuron populations to identify Gmeb1 as a novel transcriptional regulator of mDA neurons, whose loss of function impairs motor control in mice.Luis M. TuestaMohamed N. DjekidelRenchao ChenFalong LuWengang WangBernardo L. SabatiniYi ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luis M. Tuesta Mohamed N. Djekidel Renchao Chen Falong Lu Wengang Wang Bernardo L. Sabatini Yi Zhang In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
description	Despite the known role of midbrain dopaminergic (mDA) signaling in the homeostatic control of mood and motor functions, little is known about how gene expression in these neurons is regulated. Here, authors develop an in vivo nuclear tagging and capture technique for low-input chromatin accessibility and transcriptome profiling of genetically-defined neuron populations to identify Gmeb1 as a novel transcriptional regulator of mDA neurons, whose loss of function impairs motor control in mice.
format	article
author	Luis M. Tuesta Mohamed N. Djekidel Renchao Chen Falong Lu Wengang Wang Bernardo L. Sabatini Yi Zhang
author_facet	Luis M. Tuesta Mohamed N. Djekidel Renchao Chen Falong Lu Wengang Wang Bernardo L. Sabatini Yi Zhang
author_sort	Luis M. Tuesta
title	In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
title_short	In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
title_full	In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
title_fullStr	In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
title_full_unstemmed	In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function
title_sort	in vivo nuclear capture and molecular profiling identifies gmeb1 as a transcriptional regulator essential for dopamine neuron function
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/30e693ae83634bd09940961f8cef6c42
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In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function

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