BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory

Abstract BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient symptoms and, in some cases, have led to increased adv...

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Autores principales: A. Nash, H. J. M. Gijsen, B. J. Hrupka, K. S.-L. Teng, S. F. Lichtenthaler, H. Takeshima, J. M. Gunnersen, K. M. Munro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/30fc73a123fe4f83943a0c12121c8a83
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