DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

<h4>Background</h4>The natural triterpenes, erythrodiol and uvaol, exert anti-inflammatory, vasorelaxing and anti-proliferative effects. Angiotensin II is a well-known profibrotic and proliferative agent that participates in the cardiac remodeling associated with different pathological s...

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Main Authors: Ruben Martín, Maria Miana, Raquel Jurado-López, Ernesto Martínez-Martínez, Nieves Gómez-Hurtado, Carmen Delgado, Maria Visitación Bartolomé, José Alberto San Román, Claudia Cordova, Vicente Lahera, Maria Luisa Nieto, Victoria Cachofeiro
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/31318f08ff3e4b7fa18ce0a62795e37e
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