Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of...

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Main Authors: Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/314fcd580797451983c726cd599eaae1
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https://doaj.org/article/314fcd580797451983c726cd599eaae1

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