Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of...

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Autores principales:	Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/314fcd580797451983c726cd599eaae1
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spelling	oai:doaj.org-article:314fcd580797451983c726cd599eaae12021-12-02T17:33:19ZRoquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation10.1038/s41467-018-06184-32041-1723https://doaj.org/article/314fcd580797451983c726cd599eaae12018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06184-3https://doaj.org/toc/2041-1723Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs.Katharina EssigNina KronbeckJoao C. GuimaraesClaudia LohsAndreas SchlundtAnne HoffmannGesine BehrensSven BrennerJoanna KowalskaCristina Lopez-RodriguezJacek JemielityHelmut HoltmannKristin ReicheJörg HackermüllerMichael SattlerMihaela ZavolanVigo HeissmeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katharina Essig Nina Kronbeck Joao C. Guimaraes Claudia Lohs Andreas Schlundt Anne Hoffmann Gesine Behrens Sven Brenner Joanna Kowalska Cristina Lopez-Rodriguez Jacek Jemielity Helmut Holtmann Kristin Reiche Jörg Hackermüller Michael Sattler Mihaela Zavolan Vigo Heissmeyer Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
description	Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs.
format	article
author	Katharina Essig Nina Kronbeck Joao C. Guimaraes Claudia Lohs Andreas Schlundt Anne Hoffmann Gesine Behrens Sven Brenner Joanna Kowalska Cristina Lopez-Rodriguez Jacek Jemielity Helmut Holtmann Kristin Reiche Jörg Hackermüller Michael Sattler Mihaela Zavolan Vigo Heissmeyer
author_facet	Katharina Essig Nina Kronbeck Joao C. Guimaraes Claudia Lohs Andreas Schlundt Anne Hoffmann Gesine Behrens Sven Brenner Joanna Kowalska Cristina Lopez-Rodriguez Jacek Jemielity Helmut Holtmann Kristin Reiche Jörg Hackermüller Michael Sattler Mihaela Zavolan Vigo Heissmeyer
author_sort	Katharina Essig
title	Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
title_short	Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
title_full	Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
title_fullStr	Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
title_full_unstemmed	Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
title_sort	roquin targets mrnas in a 3′-utr-specific manner by different modes of regulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/314fcd580797451983c726cd599eaae1
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Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

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