PPAR agonist-induced reduction of Mcp1 in atherosclerotic plaques of obese, insulin-resistant mice depends on adiponectin-induced Irak3 expression.
Synthetic peroxisome proliferator-activated receptor (PPAR) agonists are used to treat dyslipidemia and insulin resistance. In this study, we examined molecular mechanisms that explain differential effects of a PPARα agonist (fenofibrate) and a PPARγ agonist (rosiglitazone) on macrophages during obe...
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Main Authors: | , , , , |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
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Subjects: | |
Online Access: | https://doaj.org/article/315a684639b74a6084a423564836f22e |
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