Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Arthritis affects different joints variably despite systemic inflammatory cues. Here the authors show anatomical differences in the transcriptome, epigenome and function of synovial fibroblasts that might affect susceptibility to site-specific joint diseases.

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Autores principales: Mojca Frank-Bertoncelj, Michelle Trenkmann, Kerstin Klein, Emmanuel Karouzakis, Hubert Rehrauer, Anna Bratus, Christoph Kolling, Maria Armaka, Andrew Filer, Beat A. Michel, Renate E. Gay, Christopher D. Buckley, George Kollias, Steffen Gay, Caroline Ospelt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/316497af76764c49b96164a02648272a
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spelling oai:doaj.org-article:316497af76764c49b96164a02648272a2021-12-02T17:06:04ZEpigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions10.1038/ncomms148522041-1723https://doaj.org/article/316497af76764c49b96164a02648272a2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14852https://doaj.org/toc/2041-1723Arthritis affects different joints variably despite systemic inflammatory cues. Here the authors show anatomical differences in the transcriptome, epigenome and function of synovial fibroblasts that might affect susceptibility to site-specific joint diseases.Mojca Frank-BertonceljMichelle TrenkmannKerstin KleinEmmanuel KarouzakisHubert RehrauerAnna BratusChristoph KollingMaria ArmakaAndrew FilerBeat A. MichelRenate E. GayChristopher D. BuckleyGeorge KolliasSteffen GayCaroline OspeltNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mojca Frank-Bertoncelj
Michelle Trenkmann
Kerstin Klein
Emmanuel Karouzakis
Hubert Rehrauer
Anna Bratus
Christoph Kolling
Maria Armaka
Andrew Filer
Beat A. Michel
Renate E. Gay
Christopher D. Buckley
George Kollias
Steffen Gay
Caroline Ospelt
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
description Arthritis affects different joints variably despite systemic inflammatory cues. Here the authors show anatomical differences in the transcriptome, epigenome and function of synovial fibroblasts that might affect susceptibility to site-specific joint diseases.
format article
author Mojca Frank-Bertoncelj
Michelle Trenkmann
Kerstin Klein
Emmanuel Karouzakis
Hubert Rehrauer
Anna Bratus
Christoph Kolling
Maria Armaka
Andrew Filer
Beat A. Michel
Renate E. Gay
Christopher D. Buckley
George Kollias
Steffen Gay
Caroline Ospelt
author_facet Mojca Frank-Bertoncelj
Michelle Trenkmann
Kerstin Klein
Emmanuel Karouzakis
Hubert Rehrauer
Anna Bratus
Christoph Kolling
Maria Armaka
Andrew Filer
Beat A. Michel
Renate E. Gay
Christopher D. Buckley
George Kollias
Steffen Gay
Caroline Ospelt
author_sort Mojca Frank-Bertoncelj
title Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
title_short Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
title_full Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
title_fullStr Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
title_full_unstemmed Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
title_sort epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/316497af76764c49b96164a02648272a
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