T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT or T cell proliferation assay is used has a major...

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Autores principales:	Ane Ogbe, Barbara Kronsteiner, Donal T. Skelly, Matthew Pace, Anthony Brown, Emily Adland, Kareena Adair, Hossain Delowar Akhter, Mohammad Ali, Serat-E Ali, Adrienn Angyal, M. Azim Ansari, Carolina V. Arancibia-Cárcamo, Helen Brown, Senthil Chinnakannan, Christopher Conlon, Catherine de Lara, Thushan de Silva, Christina Dold, Tao Dong, Timothy Donnison, David Eyre, Amy Flaxman, Helen Fletcher, Joshua Gardner, James T. Grist, Carl-Philipp Hackstein, Kanoot Jaruthamsophon, Katie Jeffery, Teresa Lambe, Lian Lee, Wenqin Li, Nicholas Lim, Philippa C. Matthews, Alexander J. Mentzer, Shona C. Moore, Dean J. Naisbitt, Monday Ogese, Graham Ogg, Peter Openshaw, Munir Pirmohamed, Andrew J. Pollard, Narayan Ramamurthy, Patpong Rongkard, Sarah Rowland-Jones, Oliver Sampson, Gavin Screaton, Alessandro Sette, Lizzie Stafford, Craig Thompson, Paul J. Thomson, Ryan Thwaites, Vinicius Vieira, Daniela Weiskopf, Panagiota Zacharopoulou, Oxford Immunology Network Covid-19 Response T Cell Consortium, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team, Lance Turtle, Paul Klenerman, Philip Goulder, John Frater, Eleanor Barnes, Susanna Dunachie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/316bcccee68f41c8b075256474e98d3e
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spelling	oai:doaj.org-article:316bcccee68f41c8b075256474e98d3e2021-12-02T18:15:27ZT cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses10.1038/s41467-021-21856-32041-1723https://doaj.org/article/316bcccee68f41c8b075256474e98d3e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21856-3https://doaj.org/toc/2041-1723Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT or T cell proliferation assay is used has a major effect on this discriminatory ability.Ane OgbeBarbara KronsteinerDonal T. SkellyMatthew PaceAnthony BrownEmily AdlandKareena AdairHossain Delowar AkhterMohammad AliSerat-E AliAdrienn AngyalM. Azim AnsariCarolina V. Arancibia-CárcamoHelen BrownSenthil ChinnakannanChristopher ConlonCatherine de LaraThushan de SilvaChristina DoldTao DongTimothy DonnisonDavid EyreAmy FlaxmanHelen FletcherJoshua GardnerJames T. GristCarl-Philipp HacksteinKanoot JaruthamsophonKatie JefferyTeresa LambeLian LeeWenqin LiNicholas LimPhilippa C. MatthewsAlexander J. MentzerShona C. MooreDean J. NaisbittMonday OgeseGraham OggPeter OpenshawMunir PirmohamedAndrew J. PollardNarayan RamamurthyPatpong RongkardSarah Rowland-JonesOliver SampsonGavin ScreatonAlessandro SetteLizzie StaffordCraig ThompsonPaul J. ThomsonRyan ThwaitesVinicius VieiraDaniela WeiskopfPanagiota ZacharopoulouOxford Immunology Network Covid-19 Response T Cell ConsortiumOxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical TeamLance TurtlePaul KlenermanPhilip GoulderJohn FraterEleanor BarnesSusanna DunachieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ane Ogbe Barbara Kronsteiner Donal T. Skelly Matthew Pace Anthony Brown Emily Adland Kareena Adair Hossain Delowar Akhter Mohammad Ali Serat-E Ali Adrienn Angyal M. Azim Ansari Carolina V. Arancibia-Cárcamo Helen Brown Senthil Chinnakannan Christopher Conlon Catherine de Lara Thushan de Silva Christina Dold Tao Dong Timothy Donnison David Eyre Amy Flaxman Helen Fletcher Joshua Gardner James T. Grist Carl-Philipp Hackstein Kanoot Jaruthamsophon Katie Jeffery Teresa Lambe Lian Lee Wenqin Li Nicholas Lim Philippa C. Matthews Alexander J. Mentzer Shona C. Moore Dean J. Naisbitt Monday Ogese Graham Ogg Peter Openshaw Munir Pirmohamed Andrew J. Pollard Narayan Ramamurthy Patpong Rongkard Sarah Rowland-Jones Oliver Sampson Gavin Screaton Alessandro Sette Lizzie Stafford Craig Thompson Paul J. Thomson Ryan Thwaites Vinicius Vieira Daniela Weiskopf Panagiota Zacharopoulou Oxford Immunology Network Covid-19 Response T Cell Consortium Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team Lance Turtle Paul Klenerman Philip Goulder John Frater Eleanor Barnes Susanna Dunachie T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
description	Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT or T cell proliferation assay is used has a major effect on this discriminatory ability.
format	article
author	Ane Ogbe Barbara Kronsteiner Donal T. Skelly Matthew Pace Anthony Brown Emily Adland Kareena Adair Hossain Delowar Akhter Mohammad Ali Serat-E Ali Adrienn Angyal M. Azim Ansari Carolina V. Arancibia-Cárcamo Helen Brown Senthil Chinnakannan Christopher Conlon Catherine de Lara Thushan de Silva Christina Dold Tao Dong Timothy Donnison David Eyre Amy Flaxman Helen Fletcher Joshua Gardner James T. Grist Carl-Philipp Hackstein Kanoot Jaruthamsophon Katie Jeffery Teresa Lambe Lian Lee Wenqin Li Nicholas Lim Philippa C. Matthews Alexander J. Mentzer Shona C. Moore Dean J. Naisbitt Monday Ogese Graham Ogg Peter Openshaw Munir Pirmohamed Andrew J. Pollard Narayan Ramamurthy Patpong Rongkard Sarah Rowland-Jones Oliver Sampson Gavin Screaton Alessandro Sette Lizzie Stafford Craig Thompson Paul J. Thomson Ryan Thwaites Vinicius Vieira Daniela Weiskopf Panagiota Zacharopoulou Oxford Immunology Network Covid-19 Response T Cell Consortium Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team Lance Turtle Paul Klenerman Philip Goulder John Frater Eleanor Barnes Susanna Dunachie
author_facet	Ane Ogbe Barbara Kronsteiner Donal T. Skelly Matthew Pace Anthony Brown Emily Adland Kareena Adair Hossain Delowar Akhter Mohammad Ali Serat-E Ali Adrienn Angyal M. Azim Ansari Carolina V. Arancibia-Cárcamo Helen Brown Senthil Chinnakannan Christopher Conlon Catherine de Lara Thushan de Silva Christina Dold Tao Dong Timothy Donnison David Eyre Amy Flaxman Helen Fletcher Joshua Gardner James T. Grist Carl-Philipp Hackstein Kanoot Jaruthamsophon Katie Jeffery Teresa Lambe Lian Lee Wenqin Li Nicholas Lim Philippa C. Matthews Alexander J. Mentzer Shona C. Moore Dean J. Naisbitt Monday Ogese Graham Ogg Peter Openshaw Munir Pirmohamed Andrew J. Pollard Narayan Ramamurthy Patpong Rongkard Sarah Rowland-Jones Oliver Sampson Gavin Screaton Alessandro Sette Lizzie Stafford Craig Thompson Paul J. Thomson Ryan Thwaites Vinicius Vieira Daniela Weiskopf Panagiota Zacharopoulou Oxford Immunology Network Covid-19 Response T Cell Consortium Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team Lance Turtle Paul Klenerman Philip Goulder John Frater Eleanor Barnes Susanna Dunachie
author_sort	Ane Ogbe
title	T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
title_short	T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
title_full	T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
title_fullStr	T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
title_full_unstemmed	T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
title_sort	t cell assays differentiate clinical and subclinical sars-cov-2 infections from cross-reactive antiviral responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/316bcccee68f41c8b075256474e98d3e
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T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

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