Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3. Here, the authors present the structure of SIV Nef bound to the ExxxLM motif of another Nef molecule, which allows them to propose...

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Autores principales:	Santiago Manrique, Daniel Sauter, Florian A. Horenkamp, Sebastian Lülf, Hangxing Yu, Dominik Hotter, Kanchan Anand, Frank Kirchhoff, Matthias Geyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3181fb545a0a4070b555e5f08f37e628
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id	oai:doaj.org-article:3181fb545a0a4070b555e5f08f37e628
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spelling	oai:doaj.org-article:3181fb545a0a4070b555e5f08f37e6282021-12-02T15:37:03ZEndocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD310.1038/s41467-017-00481-z2041-1723https://doaj.org/article/3181fb545a0a4070b555e5f08f37e6282017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00481-zhttps://doaj.org/toc/2041-1723HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3. Here, the authors present the structure of SIV Nef bound to the ExxxLM motif of another Nef molecule, which allows them to propose a model how Nef recognizes these motifs in CD3 and CD4.Santiago ManriqueDaniel SauterFlorian A. HorenkampSebastian LülfHangxing YuDominik HotterKanchan AnandFrank KirchhoffMatthias GeyerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Santiago Manrique Daniel Sauter Florian A. Horenkamp Sebastian Lülf Hangxing Yu Dominik Hotter Kanchan Anand Frank Kirchhoff Matthias Geyer Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
description	HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3. Here, the authors present the structure of SIV Nef bound to the ExxxLM motif of another Nef molecule, which allows them to propose a model how Nef recognizes these motifs in CD3 and CD4.
format	article
author	Santiago Manrique Daniel Sauter Florian A. Horenkamp Sebastian Lülf Hangxing Yu Dominik Hotter Kanchan Anand Frank Kirchhoff Matthias Geyer
author_facet	Santiago Manrique Daniel Sauter Florian A. Horenkamp Sebastian Lülf Hangxing Yu Dominik Hotter Kanchan Anand Frank Kirchhoff Matthias Geyer
author_sort	Santiago Manrique
title	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
title_short	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
title_full	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
title_fullStr	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
title_full_unstemmed	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
title_sort	endocytic sorting motif interactions involved in nef-mediated downmodulation of cd4 and cd3
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3181fb545a0a4070b555e5f08f37e628
work_keys_str_mv	AT santiagomanrique endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT danielsauter endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT florianahorenkamp endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT sebastianlulf endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT hangxingyu endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT dominikhotter endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT kanchananand endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT frankkirchhoff endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3 AT matthiasgeyer endocyticsortingmotifinteractionsinvolvedinnefmediateddownmodulationofcd4andcd3
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Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

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