Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.

por Sebastian Breuer, Simone I Schievink, Antje Schulte, Wulf Blankenfeldt, Oliver T Fackler, Matthias Geyer
Publicado 2011

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

por Ines H. Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Düster, Jinhua Wang, Nathanael S. Gray, Matthias Geyer
Publicado 2021

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain.

por Annika Järviluoma, Tomas Strandin, Sebastian Lülf, Jérôme Bouchet, Anna R Mäkelä, Matthias Geyer, Serge Benichou, Kalle Saksela
Publicado 2012

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

por Santiago Manrique, Daniel Sauter, Florian A. Horenkamp, Sebastian Lülf, Hangxing Yu, Dominik Hotter, Kanchan Anand, Frank Kirchhoff, Matthias Geyer
Publicado 2017

HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

por Giorgio Mangino, Zulema A Percario, Gianna Fiorucci, Gabriele Vaccari, Filippo Acconcia, Cristiano Chiarabelli, Stefano Leone, Alessia Noto, Florian A Horenkamp, Santiago Manrique, Giovanna Romeo, Fabio Polticelli, Matthias Geyer, Elisabetta Affabris
Publicado 2011

Alternative splicing regulates stochastic NLRP3 activity

por Florian Hoss, James L. Mueller, Francisca Rojas Ringeling, Juan F. Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D. Putnam, Richard D. Kolodner, Stefan Canzar, Matthias Geyer, Hal M. Hoffman, Eicke Latz
Publicado 2019

FMNL formins boost lamellipodial force generation

por Frieda Kage, Moritz Winterhoff, Vanessa Dimchev, Jan Mueller, Tobias Thalheim, Anika Freise, Stefan Brühmann, Jana Kollasser, Jennifer Block, Georgi Dimchev, Matthias Geyer, Hans-Joachim Schnittler, Cord Brakebusch, Theresia E. B. Stradal, Marie-France Carlier, Michael Sixt, Josef Käs, Jan Faix, Klemens Rottner
Publicado 2017

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

por Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George
Publicado 2019