Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Xiaohua Pei,1,* Shuyuan Lai,1,* Xianglan He,1 Nakimera Pearl Masembe,1 Haichuan Yuan,1 Zhenzhu Yong,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Geriatric Respiration...

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Autores principales: Pei XH, Lai SY, He XL, Masembe NP, Yuan HC, Yong ZZ, Zhu B, Wu JQ, Zhao WH
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Lenguaje:EN
Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:318d0465d16843968399269d12d658022021-12-02T07:57:07ZMild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study1178-1998https://doaj.org/article/318d0465d16843968399269d12d658022018-12-01T00:00:00Zhttps://www.dovepress.com/mild-cognitive-impairment-in-maintenance-hemodialysis-patients-a-cross-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xiaohua Pei,1,* Shuyuan Lai,1,* Xianglan He,1 Nakimera Pearl Masembe,1 Haichuan Yuan,1 Zhenzhu Yong,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Geriatric Respiration, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China *These authors contributed equally to this work Introduction: Few studies focused on mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients. This study was conducted to survey the prevalence, the potent risk factors of MCI in MHD patients, and further observe the progress of MCI in a period of 6 months. Methodology: Mini-Mental State Examination, and Montreal Cognitive Assessment were used to assess cognitive condition. MHD patients were enrolled from The First Affiliated Hospital of Nanjing Medical University, who had a stable hemodialysis history for more than 3 months. Results: Sixty-four MHD patients and 54 general subjects were finally included. The average age of both groups was more than 60 years. The prevalence of MCI in the MHD group was significantly higher than that in general population (60.9% vs 29.6%, P<0.05). Spearman correlation analysis indicated that MCI was related to age, comorbidities, education years, uric acid, serum albumin, and blood pressure. The prevalence and severity of MCI in the MHD group remained unchanged during the 6 months (prevalence: 59.5%–66.6%, MoCA scores: 22.9–22.5). Conclusion: MHD patients sustain a fairly high prevalence of MCI. Multiple risk factors influence the incidence and progression of MCI in MHD patients. More attention should be paid to this special population. Keywords: dementia, end stage renal disease, Montreal Cognitive Assessment, Mini-Mental State ExaminationPei XHLai SYHe XLMasembe NPYuan HCYong ZZZhu BWu JQZhao WHDove Medical PressarticleMild cognitive impairmentHemodialysisMontreal Cognitive AssessmentMini Mental State Examination.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 27-32 (2018)
institution DOAJ
collection DOAJ
language EN
topic Mild cognitive impairment
Hemodialysis
Montreal Cognitive Assessment
Mini Mental State Examination.
Geriatrics
RC952-954.6
spellingShingle Mild cognitive impairment
Hemodialysis
Montreal Cognitive Assessment
Mini Mental State Examination.
Geriatrics
RC952-954.6
Pei XH
Lai SY
He XL
Masembe NP
Yuan HC
Yong ZZ
Zhu B
Wu JQ
Zhao WH
Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
description Xiaohua Pei,1,* Shuyuan Lai,1,* Xianglan He,1 Nakimera Pearl Masembe,1 Haichuan Yuan,1 Zhenzhu Yong,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Geriatric Respiration, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China *These authors contributed equally to this work Introduction: Few studies focused on mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients. This study was conducted to survey the prevalence, the potent risk factors of MCI in MHD patients, and further observe the progress of MCI in a period of 6 months. Methodology: Mini-Mental State Examination, and Montreal Cognitive Assessment were used to assess cognitive condition. MHD patients were enrolled from The First Affiliated Hospital of Nanjing Medical University, who had a stable hemodialysis history for more than 3 months. Results: Sixty-four MHD patients and 54 general subjects were finally included. The average age of both groups was more than 60 years. The prevalence of MCI in the MHD group was significantly higher than that in general population (60.9% vs 29.6%, P<0.05). Spearman correlation analysis indicated that MCI was related to age, comorbidities, education years, uric acid, serum albumin, and blood pressure. The prevalence and severity of MCI in the MHD group remained unchanged during the 6 months (prevalence: 59.5%–66.6%, MoCA scores: 22.9–22.5). Conclusion: MHD patients sustain a fairly high prevalence of MCI. Multiple risk factors influence the incidence and progression of MCI in MHD patients. More attention should be paid to this special population. Keywords: dementia, end stage renal disease, Montreal Cognitive Assessment, Mini-Mental State Examination
format article
author Pei XH
Lai SY
He XL
Masembe NP
Yuan HC
Yong ZZ
Zhu B
Wu JQ
Zhao WH
author_facet Pei XH
Lai SY
He XL
Masembe NP
Yuan HC
Yong ZZ
Zhu B
Wu JQ
Zhao WH
author_sort Pei XH
title Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
title_short Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
title_full Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
title_fullStr Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
title_full_unstemmed Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
title_sort mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/318d0465d16843968399269d12d65802
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