Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

A common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.

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Bibliographic Details
Main Authors: Miriam Colombo, Luisa Fiandra, Giulia Alessio, Serena Mazzucchelli, Manuela Nebuloni, Clara De Palma, Karsten Kantner, Beatriz Pelaz, Rany Rotem, Fabio Corsi, Wolfgang J. Parak, Davide Prosperi
Format: article
Language:EN
Published: Nature Portfolio 2016
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Q
Online Access:https://doaj.org/article/31b037daafdb46eeb3c7cc68a126dbc7
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