Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

A common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.

Guardado en:

Detalles Bibliográficos
Autores principales:	Miriam Colombo, Luisa Fiandra, Giulia Alessio, Serena Mazzucchelli, Manuela Nebuloni, Clara De Palma, Karsten Kantner, Beatriz Pelaz, Rany Rotem, Fabio Corsi, Wolfgang J. Parak, Davide Prosperi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31b037daafdb46eeb3c7cc68a126dbc7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31b037daafdb46eeb3c7cc68a126dbc7
record_format	dspace
spelling	oai:doaj.org-article:31b037daafdb46eeb3c7cc68a126dbc72021-12-02T16:50:14ZTumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies10.1038/ncomms138182041-1723https://doaj.org/article/31b037daafdb46eeb3c7cc68a126dbc72016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13818https://doaj.org/toc/2041-1723A common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.Miriam ColomboLuisa FiandraGiulia AlessioSerena MazzucchelliManuela NebuloniClara De PalmaKarsten KantnerBeatriz PelazRany RotemFabio CorsiWolfgang J. ParakDavide ProsperiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miriam Colombo Luisa Fiandra Giulia Alessio Serena Mazzucchelli Manuela Nebuloni Clara De Palma Karsten Kantner Beatriz Pelaz Rany Rotem Fabio Corsi Wolfgang J. Parak Davide Prosperi Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
description	A common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.
format	article
author	Miriam Colombo Luisa Fiandra Giulia Alessio Serena Mazzucchelli Manuela Nebuloni Clara De Palma Karsten Kantner Beatriz Pelaz Rany Rotem Fabio Corsi Wolfgang J. Parak Davide Prosperi
author_facet	Miriam Colombo Luisa Fiandra Giulia Alessio Serena Mazzucchelli Manuela Nebuloni Clara De Palma Karsten Kantner Beatriz Pelaz Rany Rotem Fabio Corsi Wolfgang J. Parak Davide Prosperi
author_sort	Miriam Colombo
title	Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_short	Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_full	Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_fullStr	Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_full_unstemmed	Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_sort	tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/31b037daafdb46eeb3c7cc68a126dbc7
work_keys_str_mv	AT miriamcolombo tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT luisafiandra tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT giuliaalessio tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT serenamazzucchelli tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT manuelanebuloni tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT claradepalma tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT karstenkantner tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT beatrizpelaz tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT ranyrotem tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT fabiocorsi tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT wolfgangjparak tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies AT davideprosperi tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies
_version_	1718383089060675584

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

Ejemplares similares