Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection.

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Autores principales:	Kira L. Tomlinson, Tania Wong Fok Lung, Felix Dach, Medini K. Annavajhala, Stanislaw J. Gabryszewski, Ryan A. Groves, Marija Drikic, Nancy J. Francoeur, Shwetha H. Sridhar, Melissa L. Smith, Sara Khanal, Clemente J. Britto, Robert Sebra, Ian Lewis, Anne-Catrin Uhlemann, Barbara C. Kahl, Alice S. Prince, Sebastián A. Riquelme
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31b0833e7deb4acab5af4327ac64931d
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spelling	oai:doaj.org-article:31b0833e7deb4acab5af4327ac64931d2021-12-02T13:14:47ZStaphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation10.1038/s41467-021-21718-y2041-1723https://doaj.org/article/31b0833e7deb4acab5af4327ac64931d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21718-yhttps://doaj.org/toc/2041-1723The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection.Kira L. TomlinsonTania Wong Fok LungFelix DachMedini K. AnnavajhalaStanislaw J. GabryszewskiRyan A. GrovesMarija DrikicNancy J. FrancoeurShwetha H. SridharMelissa L. SmithSara KhanalClemente J. BrittoRobert SebraIan LewisAnne-Catrin UhlemannBarbara C. KahlAlice S. PrinceSebastián A. RiquelmeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kira L. Tomlinson Tania Wong Fok Lung Felix Dach Medini K. Annavajhala Stanislaw J. Gabryszewski Ryan A. Groves Marija Drikic Nancy J. Francoeur Shwetha H. Sridhar Melissa L. Smith Sara Khanal Clemente J. Britto Robert Sebra Ian Lewis Anne-Catrin Uhlemann Barbara C. Kahl Alice S. Prince Sebastián A. Riquelme Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
description	The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection.
format	article
author	Kira L. Tomlinson Tania Wong Fok Lung Felix Dach Medini K. Annavajhala Stanislaw J. Gabryszewski Ryan A. Groves Marija Drikic Nancy J. Francoeur Shwetha H. Sridhar Melissa L. Smith Sara Khanal Clemente J. Britto Robert Sebra Ian Lewis Anne-Catrin Uhlemann Barbara C. Kahl Alice S. Prince Sebastián A. Riquelme
author_facet	Kira L. Tomlinson Tania Wong Fok Lung Felix Dach Medini K. Annavajhala Stanislaw J. Gabryszewski Ryan A. Groves Marija Drikic Nancy J. Francoeur Shwetha H. Sridhar Melissa L. Smith Sara Khanal Clemente J. Britto Robert Sebra Ian Lewis Anne-Catrin Uhlemann Barbara C. Kahl Alice S. Prince Sebastián A. Riquelme
author_sort	Kira L. Tomlinson
title	Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
title_short	Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
title_full	Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
title_fullStr	Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
title_full_unstemmed	Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
title_sort	staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/31b0833e7deb4acab5af4327ac64931d
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Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

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