Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. The etiology and pathogenesis of ALS are being actively studied, but...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Polina S. Goncharova, Tatiana K. Davydova, Tatiana E. Popova, Maxim A. Novitsky, Marina M. Petrova, Oksana A. Gavrilyuk, Mustafa Al-Zamil, Natalia G. Zhukova, Regina F. Nasyrova, Natalia A. Shnayder
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	amyotrophic lateral sclerosis predictor risk factor protector nutrient vitamin Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/31c478ed9cbf4a7d9e5b00604f16cb76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31c478ed9cbf4a7d9e5b00604f16cb76
record_format	dspace
spelling	oai:doaj.org-article:31c478ed9cbf4a7d9e5b00604f16cb762021-11-25T18:34:16ZNutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis10.3390/nu131138042072-6643https://doaj.org/article/31c478ed9cbf4a7d9e5b00604f16cb762021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3804https://doaj.org/toc/2072-6643Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. The etiology and pathogenesis of ALS are being actively studied, but there is still no single concept. The study of ALS risk factors can help to understand the mechanism of this disease development and, possibly, slow down the rate of its progression in patients and also reduce the risk of its development in people with a predisposition toward familial ALS. The interest of researchers and clinicians in the protective role of nutrients in the development of ALS has been increasing in recent years. However, the role of some of them is not well-understood or disputed. The objective of this review is to analyze studies on the role of nutrients as environmental factors affecting the risk of developing ALS and the rate of motor neuron degeneration progression. Methods: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications using keywords and their combinations. We analyzed all the available studies published in 2010–2020. Discussion: We analyzed 39 studies, including randomized clinical trials, clinical cases, and meta-analyses, involving ALS patients and studies on animal models of ALS. This review demonstrated that the following vitamins are the most significant protectors of ALS development: vitamin B12, vitamin E > vitamin C > vitamin B1, vitamin B9 > vitamin D > vitamin B2, vitamin B6 > vitamin A, and vitamin B7. In addition, this review indicates that the role of foods with a high content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a big part in ALS development. Conclusion: The inclusion of vitamins and a ketogenic diet in disease-modifying ALS therapy can reduce the progression rate of motor neuron degeneration and slow the rate of disease progression, but the approach to nutrient selection must be personalized. The roles of vitamins C, D, and B7 as ALS protectors need further study.Polina S. GoncharovaTatiana K. DavydovaTatiana E. PopovaMaxim A. NovitskyMarina M. PetrovaOksana A. GavrilyukMustafa Al-ZamilNatalia G. ZhukovaRegina F. NasyrovaNatalia A. ShnayderMDPI AGarticleamyotrophic lateral sclerosispredictorrisk factorprotectornutrientvitaminNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3804, p 3804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyotrophic lateral sclerosis predictor risk factor protector nutrient vitamin Nutrition. Foods and food supply TX341-641
spellingShingle	amyotrophic lateral sclerosis predictor risk factor protector nutrient vitamin Nutrition. Foods and food supply TX341-641 Polina S. Goncharova Tatiana K. Davydova Tatiana E. Popova Maxim A. Novitsky Marina M. Petrova Oksana A. Gavrilyuk Mustafa Al-Zamil Natalia G. Zhukova Regina F. Nasyrova Natalia A. Shnayder Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
description	Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. The etiology and pathogenesis of ALS are being actively studied, but there is still no single concept. The study of ALS risk factors can help to understand the mechanism of this disease development and, possibly, slow down the rate of its progression in patients and also reduce the risk of its development in people with a predisposition toward familial ALS. The interest of researchers and clinicians in the protective role of nutrients in the development of ALS has been increasing in recent years. However, the role of some of them is not well-understood or disputed. The objective of this review is to analyze studies on the role of nutrients as environmental factors affecting the risk of developing ALS and the rate of motor neuron degeneration progression. Methods: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications using keywords and their combinations. We analyzed all the available studies published in 2010–2020. Discussion: We analyzed 39 studies, including randomized clinical trials, clinical cases, and meta-analyses, involving ALS patients and studies on animal models of ALS. This review demonstrated that the following vitamins are the most significant protectors of ALS development: vitamin B12, vitamin E > vitamin C > vitamin B1, vitamin B9 > vitamin D > vitamin B2, vitamin B6 > vitamin A, and vitamin B7. In addition, this review indicates that the role of foods with a high content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a big part in ALS development. Conclusion: The inclusion of vitamins and a ketogenic diet in disease-modifying ALS therapy can reduce the progression rate of motor neuron degeneration and slow the rate of disease progression, but the approach to nutrient selection must be personalized. The roles of vitamins C, D, and B7 as ALS protectors need further study.
format	article
author	Polina S. Goncharova Tatiana K. Davydova Tatiana E. Popova Maxim A. Novitsky Marina M. Petrova Oksana A. Gavrilyuk Mustafa Al-Zamil Natalia G. Zhukova Regina F. Nasyrova Natalia A. Shnayder
author_facet	Polina S. Goncharova Tatiana K. Davydova Tatiana E. Popova Maxim A. Novitsky Marina M. Petrova Oksana A. Gavrilyuk Mustafa Al-Zamil Natalia G. Zhukova Regina F. Nasyrova Natalia A. Shnayder
author_sort	Polina S. Goncharova
title	Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
title_short	Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
title_full	Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
title_fullStr	Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
title_full_unstemmed	Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis
title_sort	nutrient effects on motor neurons and the risk of amyotrophic lateral sclerosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/31c478ed9cbf4a7d9e5b00604f16cb76
work_keys_str_mv	AT polinasgoncharova nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT tatianakdavydova nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT tatianaepopova nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT maximanovitsky nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT marinampetrova nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT oksanaagavrilyuk nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT mustafaalzamil nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT nataliagzhukova nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT reginafnasyrova nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis AT nataliaashnayder nutrienteffectsonmotorneuronsandtheriskofamyotrophiclateralsclerosis
_version_	1718410943627526144

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Ejemplares similares