Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.

The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the available icariin-derived chemical scaffolds through medicinal chemistry to develop...

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Autores principales: Yasmin Chau, Fu-Shuang Li, Olesya Levsh, Jing-Ke Weng
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2019
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Acceso en línea:https://doaj.org/article/31d1213b0d3b4491a4776060b1a4f923
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