Directed evolution of rRNA improves translation kinetics and recombinant protein yield

Ribosome kinetics are rate-limiting for protein synthesis. Here the authors evolve diverse 16S rRNAs for enhanced protein synthesis rates and genetic code expansion efficiencies in vivo.

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Autores principales: Fan Liu, Siniša Bratulić, Alan Costello, Teemu P. Miettinen, Ahmed H. Badran
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/32003b95f3524e2ca3a03d553664173a
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