Directed evolution of rRNA improves translation kinetics and recombinant protein yield

Ribosome kinetics are rate-limiting for protein synthesis. Here the authors evolve diverse 16S rRNAs for enhanced protein synthesis rates and genetic code expansion efficiencies in vivo.

Guardado en:

Detalles Bibliográficos
Autores principales:	Fan Liu, Siniša Bratulić, Alan Costello, Teemu P. Miettinen, Ahmed H. Badran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32003b95f3524e2ca3a03d553664173a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:32003b95f3524e2ca3a03d553664173a
record_format	dspace
spelling	oai:doaj.org-article:32003b95f3524e2ca3a03d553664173a2021-12-02T18:48:11ZDirected evolution of rRNA improves translation kinetics and recombinant protein yield10.1038/s41467-021-25852-52041-1723https://doaj.org/article/32003b95f3524e2ca3a03d553664173a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25852-5https://doaj.org/toc/2041-1723Ribosome kinetics are rate-limiting for protein synthesis. Here the authors evolve diverse 16S rRNAs for enhanced protein synthesis rates and genetic code expansion efficiencies in vivo.Fan LiuSiniša BratulićAlan CostelloTeemu P. MiettinenAhmed H. BadranNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fan Liu Siniša Bratulić Alan Costello Teemu P. Miettinen Ahmed H. Badran Directed evolution of rRNA improves translation kinetics and recombinant protein yield
description	Ribosome kinetics are rate-limiting for protein synthesis. Here the authors evolve diverse 16S rRNAs for enhanced protein synthesis rates and genetic code expansion efficiencies in vivo.
format	article
author	Fan Liu Siniša Bratulić Alan Costello Teemu P. Miettinen Ahmed H. Badran
author_facet	Fan Liu Siniša Bratulić Alan Costello Teemu P. Miettinen Ahmed H. Badran
author_sort	Fan Liu
title	Directed evolution of rRNA improves translation kinetics and recombinant protein yield
title_short	Directed evolution of rRNA improves translation kinetics and recombinant protein yield
title_full	Directed evolution of rRNA improves translation kinetics and recombinant protein yield
title_fullStr	Directed evolution of rRNA improves translation kinetics and recombinant protein yield
title_full_unstemmed	Directed evolution of rRNA improves translation kinetics and recombinant protein yield
title_sort	directed evolution of rrna improves translation kinetics and recombinant protein yield
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/32003b95f3524e2ca3a03d553664173a
work_keys_str_mv	AT fanliu directedevolutionofrrnaimprovestranslationkineticsandrecombinantproteinyield AT sinisabratulic directedevolutionofrrnaimprovestranslationkineticsandrecombinantproteinyield AT alancostello directedevolutionofrrnaimprovestranslationkineticsandrecombinantproteinyield AT teemupmiettinen directedevolutionofrrnaimprovestranslationkineticsandrecombinantproteinyield AT ahmedhbadran directedevolutionofrrnaimprovestranslationkineticsandrecombinantproteinyield
_version_	1718377614842789888

Directed evolution of rRNA improves translation kinetics and recombinant protein yield

Ejemplares similares