Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study sugge...

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Autores principales: Kushal Suryamohan, Devan Diwanji, Eric W. Stawiski, Ravi Gupta, Shane Miersch, Jiang Liu, Chao Chen, Ying-Ping Jiang, Frederic A. Fellouse, J. Fah Sathirapongsasuti, Patrick K. Albers, Tanneeru Deepak, Reza Saberianfar, Aakrosh Ratan, Gavin Washburn, Monika Mis, Devi Santhosh, Sneha Somasekar, G. H. Hiranjith, Derek Vargas, Sangeetha Mohan, Sameer Phalke, Boney Kuriakose, Aju Antony, Mart Ustav Jr, Stephan C. Schuster, Sachdev Sidhu, Jagath R. Junutula, Natalia Jura, Somasekar Seshagiri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/32225ac91a454b1683c6a373e209aa04
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spelling oai:doaj.org-article:32225ac91a454b1683c6a373e209aa042021-12-02T18:03:20ZHuman ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-210.1038/s42003-021-02030-32399-3642https://doaj.org/article/32225ac91a454b1683c6a373e209aa042021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02030-3https://doaj.org/toc/2399-3642Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2.Kushal SuryamohanDevan DiwanjiEric W. StawiskiRavi GuptaShane MierschJiang LiuChao ChenYing-Ping JiangFrederic A. FellouseJ. Fah SathirapongsasutiPatrick K. AlbersTanneeru DeepakReza SaberianfarAakrosh RatanGavin WashburnMonika MisDevi SanthoshSneha SomasekarG. H. HiranjithDerek VargasSangeetha MohanSameer PhalkeBoney KuriakoseAju AntonyMart Ustav JrStephan C. SchusterSachdev SidhuJagath R. JunutulaNatalia JuraSomasekar SeshagiriNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Kushal Suryamohan
Devan Diwanji
Eric W. Stawiski
Ravi Gupta
Shane Miersch
Jiang Liu
Chao Chen
Ying-Ping Jiang
Frederic A. Fellouse
J. Fah Sathirapongsasuti
Patrick K. Albers
Tanneeru Deepak
Reza Saberianfar
Aakrosh Ratan
Gavin Washburn
Monika Mis
Devi Santhosh
Sneha Somasekar
G. H. Hiranjith
Derek Vargas
Sangeetha Mohan
Sameer Phalke
Boney Kuriakose
Aju Antony
Mart Ustav Jr
Stephan C. Schuster
Sachdev Sidhu
Jagath R. Junutula
Natalia Jura
Somasekar Seshagiri
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
description Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2.
format article
author Kushal Suryamohan
Devan Diwanji
Eric W. Stawiski
Ravi Gupta
Shane Miersch
Jiang Liu
Chao Chen
Ying-Ping Jiang
Frederic A. Fellouse
J. Fah Sathirapongsasuti
Patrick K. Albers
Tanneeru Deepak
Reza Saberianfar
Aakrosh Ratan
Gavin Washburn
Monika Mis
Devi Santhosh
Sneha Somasekar
G. H. Hiranjith
Derek Vargas
Sangeetha Mohan
Sameer Phalke
Boney Kuriakose
Aju Antony
Mart Ustav Jr
Stephan C. Schuster
Sachdev Sidhu
Jagath R. Junutula
Natalia Jura
Somasekar Seshagiri
author_facet Kushal Suryamohan
Devan Diwanji
Eric W. Stawiski
Ravi Gupta
Shane Miersch
Jiang Liu
Chao Chen
Ying-Ping Jiang
Frederic A. Fellouse
J. Fah Sathirapongsasuti
Patrick K. Albers
Tanneeru Deepak
Reza Saberianfar
Aakrosh Ratan
Gavin Washburn
Monika Mis
Devi Santhosh
Sneha Somasekar
G. H. Hiranjith
Derek Vargas
Sangeetha Mohan
Sameer Phalke
Boney Kuriakose
Aju Antony
Mart Ustav Jr
Stephan C. Schuster
Sachdev Sidhu
Jagath R. Junutula
Natalia Jura
Somasekar Seshagiri
author_sort Kushal Suryamohan
title Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
title_short Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
title_full Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
title_fullStr Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
title_full_unstemmed Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
title_sort human ace2 receptor polymorphisms and altered susceptibility to sars-cov-2
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/32225ac91a454b1683c6a373e209aa04
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