Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide
Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transient and structurally diverse oligomeric pores in cel...
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Nature Portfolio
2016
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oai:doaj.org-article:322f5d07a3e6460aa7ea543a7dc9effb2021-12-02T17:33:10ZSpontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide10.1038/ncomms135352041-1723https://doaj.org/article/322f5d07a3e6460aa7ea543a7dc9effb2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13535https://doaj.org/toc/2041-1723Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transient and structurally diverse oligomeric pores in cell membranes.Yukun WangCharles H. ChenDan HuMartin B. UlmschneiderJakob P. UlmschneiderNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
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Science Q Yukun Wang Charles H. Chen Dan Hu Martin B. Ulmschneider Jakob P. Ulmschneider Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
description |
Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transient and structurally diverse oligomeric pores in cell membranes. |
format |
article |
author |
Yukun Wang Charles H. Chen Dan Hu Martin B. Ulmschneider Jakob P. Ulmschneider |
author_facet |
Yukun Wang Charles H. Chen Dan Hu Martin B. Ulmschneider Jakob P. Ulmschneider |
author_sort |
Yukun Wang |
title |
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
title_short |
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
title_full |
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
title_fullStr |
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
title_full_unstemmed |
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
title_sort |
spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/322f5d07a3e6460aa7ea543a7dc9effb |
work_keys_str_mv |
AT yukunwang spontaneousformationofstructurallydiversemembranechannelarchitecturesfromasingleantimicrobialpeptide AT charleshchen spontaneousformationofstructurallydiversemembranechannelarchitecturesfromasingleantimicrobialpeptide AT danhu spontaneousformationofstructurallydiversemembranechannelarchitecturesfromasingleantimicrobialpeptide AT martinbulmschneider spontaneousformationofstructurallydiversemembranechannelarchitecturesfromasingleantimicrobialpeptide AT jakobpulmschneider spontaneousformationofstructurallydiversemembranechannelarchitecturesfromasingleantimicrobialpeptide |
_version_ |
1718380054386311168 |