Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion
ABSTRACT Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross-protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate th...
Guardado en:
Autores principales: | Lisa C. Lindesmith, Michael L. Mallory, Kari Debbink, Eric F. Donaldson, Paul D. Brewer-Jensen, Excel W. Swann, Timothy P. Sheahan, Rachel L. Graham, Martina Beltramello, Davide Corti, Antonio Lanzavecchia, Ralph S. Baric |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3234b0dad85f46aab63b050645be5abc |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
IMMUNE EPITOPE CONTINUUM OF THE PROTEIN RELATIONSHIPS, POLY- AND AUTOREACTIVITY OF ANTIBODIES
por: E. P. Kharchenko
Publicado: (2015) -
AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition
por: Anjali Singh, et al.
Publicado: (2019) -
A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies
por: Meredith E. Davis-Gardner, et al.
Publicado: (2020) -
Immunological strategy for detecting the pro-inflammatory cytokine TNF-alpha in salmonids
por: Rojas,Verónica, et al.
Publicado: (2012) -
Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation
por: Christina Guzzo, et al.
Publicado: (2018)