Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

Hypoxia induced during inflammation promotes the resolution phase. Here the authors show that the hypoxia results from the respiratory burst in myeloid cells, and induces local EPO production and signaling, which enhances macrophage phagocytosis of debris and migration to draining lymph nodes to pro...

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Autores principales:	Bangwei Luo, Jinsong Wang, Zongwei Liu, Zigang Shen, Rongchen Shi, Yu-Qi Liu, Yu Liu, Man Jiang, Yuzhang Wu, Zhiren Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3257dde8948b486e9fead6e62f7fe079
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spelling	oai:doaj.org-article:3257dde8948b486e9fead6e62f7fe0792021-12-02T17:32:36ZPhagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution10.1038/ncomms121772041-1723https://doaj.org/article/3257dde8948b486e9fead6e62f7fe0792016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12177https://doaj.org/toc/2041-1723Hypoxia induced during inflammation promotes the resolution phase. Here the authors show that the hypoxia results from the respiratory burst in myeloid cells, and induces local EPO production and signaling, which enhances macrophage phagocytosis of debris and migration to draining lymph nodes to promote resolution.Bangwei LuoJinsong WangZongwei LiuZigang ShenRongchen ShiYu-Qi LiuYu LiuMan JiangYuzhang WuZhiren ZhangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bangwei Luo Jinsong Wang Zongwei Liu Zigang Shen Rongchen Shi Yu-Qi Liu Yu Liu Man Jiang Yuzhang Wu Zhiren Zhang Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
description	Hypoxia induced during inflammation promotes the resolution phase. Here the authors show that the hypoxia results from the respiratory burst in myeloid cells, and induces local EPO production and signaling, which enhances macrophage phagocytosis of debris and migration to draining lymph nodes to promote resolution.
format	article
author	Bangwei Luo Jinsong Wang Zongwei Liu Zigang Shen Rongchen Shi Yu-Qi Liu Yu Liu Man Jiang Yuzhang Wu Zhiren Zhang
author_facet	Bangwei Luo Jinsong Wang Zongwei Liu Zigang Shen Rongchen Shi Yu-Qi Liu Yu Liu Man Jiang Yuzhang Wu Zhiren Zhang
author_sort	Bangwei Luo
title	Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
title_short	Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
title_full	Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
title_fullStr	Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
title_full_unstemmed	Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
title_sort	phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3257dde8948b486e9fead6e62f7fe079
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_version_	1718380239282765824

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

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