Molecular mechanism of cytoplasmic dynein tension sensing

The cytoplasmic motor protein dynein senses directional tension; its microtubule-binding domains bind microtubules more strongly when under backward load. Here the authors use optical tweezers to show that the linker, buttress, and stalk domains together regulate directional tension-sensing.

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Detalles Bibliográficos
Autores principales:	Lu Rao, Florian Berger, Matthew P. Nicholas, Arne Gennerich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/325aff2c653c44afabe5feb61e8dc048
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spelling	oai:doaj.org-article:325aff2c653c44afabe5feb61e8dc0482021-12-02T14:40:00ZMolecular mechanism of cytoplasmic dynein tension sensing10.1038/s41467-019-11231-82041-1723https://doaj.org/article/325aff2c653c44afabe5feb61e8dc0482019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11231-8https://doaj.org/toc/2041-1723The cytoplasmic motor protein dynein senses directional tension; its microtubule-binding domains bind microtubules more strongly when under backward load. Here the authors use optical tweezers to show that the linker, buttress, and stalk domains together regulate directional tension-sensing.Lu RaoFlorian BergerMatthew P. NicholasArne GennerichNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Rao Florian Berger Matthew P. Nicholas Arne Gennerich Molecular mechanism of cytoplasmic dynein tension sensing
description	The cytoplasmic motor protein dynein senses directional tension; its microtubule-binding domains bind microtubules more strongly when under backward load. Here the authors use optical tweezers to show that the linker, buttress, and stalk domains together regulate directional tension-sensing.
format	article
author	Lu Rao Florian Berger Matthew P. Nicholas Arne Gennerich
author_facet	Lu Rao Florian Berger Matthew P. Nicholas Arne Gennerich
author_sort	Lu Rao
title	Molecular mechanism of cytoplasmic dynein tension sensing
title_short	Molecular mechanism of cytoplasmic dynein tension sensing
title_full	Molecular mechanism of cytoplasmic dynein tension sensing
title_fullStr	Molecular mechanism of cytoplasmic dynein tension sensing
title_full_unstemmed	Molecular mechanism of cytoplasmic dynein tension sensing
title_sort	molecular mechanism of cytoplasmic dynein tension sensing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/325aff2c653c44afabe5feb61e8dc048
work_keys_str_mv	AT lurao molecularmechanismofcytoplasmicdyneintensionsensing AT florianberger molecularmechanismofcytoplasmicdyneintensionsensing AT matthewpnicholas molecularmechanismofcytoplasmicdyneintensionsensing AT arnegennerich molecularmechanismofcytoplasmicdyneintensionsensing
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Molecular mechanism of cytoplasmic dynein tension sensing

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