Molecular mechanism of cytoplasmic dynein tension sensing

The cytoplasmic motor protein dynein senses directional tension; its microtubule-binding domains bind microtubules more strongly when under backward load. Here the authors use optical tweezers to show that the linker, buttress, and stalk domains together regulate directional tension-sensing.

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Detalles Bibliográficos
Autores principales: Lu Rao, Florian Berger, Matthew P. Nicholas, Arne Gennerich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/325aff2c653c44afabe5feb61e8dc048
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