GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

Chen et al. show that hippuric acid (HA), which is a diet-derived phenolic acid, inhibits bone resorption and increases bone mass in wild type mice, but not in G-protein coupled receptor (GPR109A) knockout mice. This study suggests that GPR109A mediates the effects of HA on inhibiting bone resorptio...

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Autores principales: Jin-Ran Chen, Haijun Zhao, Umesh D. Wankhade, Sree V. Chintapalli, Can Li, Dongzheng Gai, Kartik Shankar, Fenghuang Zhan, Oxana P. Lazarenko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/326219ecf5b84dbc89616cda50c648e4
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