GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

Chen et al. show that hippuric acid (HA), which is a diet-derived phenolic acid, inhibits bone resorption and increases bone mass in wild type mice, but not in G-protein coupled receptor (GPR109A) knockout mice. This study suggests that GPR109A mediates the effects of HA on inhibiting bone resorptio...

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Autores principales:	Jin-Ran Chen, Haijun Zhao, Umesh D. Wankhade, Sree V. Chintapalli, Can Li, Dongzheng Gai, Kartik Shankar, Fenghuang Zhan, Oxana P. Lazarenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/326219ecf5b84dbc89616cda50c648e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:326219ecf5b84dbc89616cda50c648e42021-12-02T15:07:32ZGPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice10.1038/s42003-020-01564-22399-3642https://doaj.org/article/326219ecf5b84dbc89616cda50c648e42021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01564-2https://doaj.org/toc/2399-3642Chen et al. show that hippuric acid (HA), which is a diet-derived phenolic acid, inhibits bone resorption and increases bone mass in wild type mice, but not in G-protein coupled receptor (GPR109A) knockout mice. This study suggests that GPR109A mediates the effects of HA on inhibiting bone resorption during skeletal development.Jin-Ran ChenHaijun ZhaoUmesh D. WankhadeSree V. ChintapalliCan LiDongzheng GaiKartik ShankarFenghuang ZhanOxana P. LazarenkoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jin-Ran Chen Haijun Zhao Umesh D. Wankhade Sree V. Chintapalli Can Li Dongzheng Gai Kartik Shankar Fenghuang Zhan Oxana P. Lazarenko GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
description	Chen et al. show that hippuric acid (HA), which is a diet-derived phenolic acid, inhibits bone resorption and increases bone mass in wild type mice, but not in G-protein coupled receptor (GPR109A) knockout mice. This study suggests that GPR109A mediates the effects of HA on inhibiting bone resorption during skeletal development.
format	article
author	Jin-Ran Chen Haijun Zhao Umesh D. Wankhade Sree V. Chintapalli Can Li Dongzheng Gai Kartik Shankar Fenghuang Zhan Oxana P. Lazarenko
author_facet	Jin-Ran Chen Haijun Zhao Umesh D. Wankhade Sree V. Chintapalli Can Li Dongzheng Gai Kartik Shankar Fenghuang Zhan Oxana P. Lazarenko
author_sort	Jin-Ran Chen
title	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
title_short	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
title_full	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
title_fullStr	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
title_full_unstemmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
title_sort	gpr109a mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/326219ecf5b84dbc89616cda50c648e4
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GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

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