Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

GWAS have so far identified 129 loci associated with type 2 diabetes (T2D). Here, the authors meta-analyse three large T2D GWA studies which uncovers 42 additional loci, further prioritize 33 functional genes using eQTL and mQTL data and propose regulatory mechanisms for three putative T2D genes.

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Detalles Bibliográficos
Autores principales: Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, eQTLGen Consortium, Allan F. McRae, Peter M. Visscher, Jian Zeng, Jian Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/32799b23a5074a0f8b6b2e7ac5c1cd6b
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https://doaj.org/article/32799b23a5074a0f8b6b2e7ac5c1cd6b

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