Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

GWAS have so far identified 129 loci associated with type 2 diabetes (T2D). Here, the authors meta-analyse three large T2D GWA studies which uncovers 42 additional loci, further prioritize 33 functional genes using eQTL and mQTL data and propose regulatory mechanisms for three putative T2D genes.

Guardado en:
Detalles Bibliográficos
Autores principales: Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, eQTLGen Consortium, Allan F. McRae, Peter M. Visscher, Jian Zeng, Jian Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/32799b23a5074a0f8b6b2e7ac5c1cd6b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares