Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma
Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-pro...
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Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/32ab3e88cf44451db91906e12159c106 |
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