Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma

Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma

Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-pro...

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Autores principales: Rocky M. Barilla, Brian Diskin, Raul Caso Caso, Ki Buom Lee, Navyatha Mohan, Chandan Buttar, Salma Adam, Zennur Sekendiz, Junjie Wang, Ruben D. Salas, Marcelo F. Cassini, Jason Karlen, Belen Sundberg, Hashem Akbar, Dmitry Levchenko, Inderdeep Gakhal, Johana Gutierrez, Wei Wang, Mautin Hundeyin, Alejandro Torres-Hernandez, Joshua Leinwand, Emma Kurz, Juan A. Kochen Rossi, Ankita Mishra, Miguel Liria, Gustavo Sanchez, Jyoti Panta, P’ng Loke, Berk Aykut, George Miller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/32ab3e88cf44451db91906e12159c106
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Sumario:Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-promoting FoxP3– Type-1 regulatory T cells.

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