Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma
Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-pro...
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Nature Portfolio
2019
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oai:doaj.org-article:32ab3e88cf44451db91906e12159c1062021-12-02T16:57:43ZSpecialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma10.1038/s41467-019-09416-22041-1723https://doaj.org/article/32ab3e88cf44451db91906e12159c1062019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09416-2https://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-promoting FoxP3– Type-1 regulatory T cells.Rocky M. BarillaBrian DiskinRaul Caso CasoKi Buom LeeNavyatha MohanChandan ButtarSalma AdamZennur SekendizJunjie WangRuben D. SalasMarcelo F. CassiniJason KarlenBelen SundbergHashem AkbarDmitry LevchenkoInderdeep GakhalJohana GutierrezWei WangMautin HundeyinAlejandro Torres-HernandezJoshua LeinwandEmma KurzJuan A. Kochen RossiAnkita MishraMiguel LiriaGustavo SanchezJyoti PantaP’ng LokeBerk AykutGeorge MillerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Rocky M. Barilla Brian Diskin Raul Caso Caso Ki Buom Lee Navyatha Mohan Chandan Buttar Salma Adam Zennur Sekendiz Junjie Wang Ruben D. Salas Marcelo F. Cassini Jason Karlen Belen Sundberg Hashem Akbar Dmitry Levchenko Inderdeep Gakhal Johana Gutierrez Wei Wang Mautin Hundeyin Alejandro Torres-Hernandez Joshua Leinwand Emma Kurz Juan A. Kochen Rossi Ankita Mishra Miguel Liria Gustavo Sanchez Jyoti Panta P’ng Loke Berk Aykut George Miller Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma |
| description |
Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-promoting FoxP3– Type-1 regulatory T cells. |
| format |
article |
| author |
Rocky M. Barilla Brian Diskin Raul Caso Caso Ki Buom Lee Navyatha Mohan Chandan Buttar Salma Adam Zennur Sekendiz Junjie Wang Ruben D. Salas Marcelo F. Cassini Jason Karlen Belen Sundberg Hashem Akbar Dmitry Levchenko Inderdeep Gakhal Johana Gutierrez Wei Wang Mautin Hundeyin Alejandro Torres-Hernandez Joshua Leinwand Emma Kurz Juan A. Kochen Rossi Ankita Mishra Miguel Liria Gustavo Sanchez Jyoti Panta P’ng Loke Berk Aykut George Miller |
| author_facet |
Rocky M. Barilla Brian Diskin Raul Caso Caso Ki Buom Lee Navyatha Mohan Chandan Buttar Salma Adam Zennur Sekendiz Junjie Wang Ruben D. Salas Marcelo F. Cassini Jason Karlen Belen Sundberg Hashem Akbar Dmitry Levchenko Inderdeep Gakhal Johana Gutierrez Wei Wang Mautin Hundeyin Alejandro Torres-Hernandez Joshua Leinwand Emma Kurz Juan A. Kochen Rossi Ankita Mishra Miguel Liria Gustavo Sanchez Jyoti Panta P’ng Loke Berk Aykut George Miller |
| author_sort |
Rocky M. Barilla |
| title |
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma |
| title_short |
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma |
| title_full |
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma |
| title_fullStr |
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma |
| title_full_unstemmed |
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma |
| title_sort |
specialized dendritic cells induce tumor-promoting il-10+il-17+ foxp3 neg regulatory cd4+ t cells in pancreatic carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/32ab3e88cf44451db91906e12159c106 |
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