LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

The interferon-induced gene LY6E increases virus infection, but the underlying mechanism is poorly understood. Here, Mar et al. show that LY6E enhances uncoating of influenza A virus after endosomal escape and that viral enhancement by LY6E is conserved across evolution.

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Autores principales:	Katrina B. Mar, Nicholas R. Rinkenberger, Ian N. Boys, Jennifer L. Eitson, Matthew B. McDougal, R. Blake Richardson, John W. Schoggins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/32b1f2d4d5494f82ad2fcf71b16e8791
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spelling	oai:doaj.org-article:32b1f2d4d5494f82ad2fcf71b16e87912021-12-02T16:49:18ZLY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step10.1038/s41467-018-06000-y2041-1723https://doaj.org/article/32b1f2d4d5494f82ad2fcf71b16e87912018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06000-yhttps://doaj.org/toc/2041-1723The interferon-induced gene LY6E increases virus infection, but the underlying mechanism is poorly understood. Here, Mar et al. show that LY6E enhances uncoating of influenza A virus after endosomal escape and that viral enhancement by LY6E is conserved across evolution.Katrina B. MarNicholas R. RinkenbergerIan N. BoysJennifer L. EitsonMatthew B. McDougalR. Blake RichardsonJohn W. SchogginsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katrina B. Mar Nicholas R. Rinkenberger Ian N. Boys Jennifer L. Eitson Matthew B. McDougal R. Blake Richardson John W. Schoggins LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
description	The interferon-induced gene LY6E increases virus infection, but the underlying mechanism is poorly understood. Here, Mar et al. show that LY6E enhances uncoating of influenza A virus after endosomal escape and that viral enhancement by LY6E is conserved across evolution.
format	article
author	Katrina B. Mar Nicholas R. Rinkenberger Ian N. Boys Jennifer L. Eitson Matthew B. McDougal R. Blake Richardson John W. Schoggins
author_facet	Katrina B. Mar Nicholas R. Rinkenberger Ian N. Boys Jennifer L. Eitson Matthew B. McDougal R. Blake Richardson John W. Schoggins
author_sort	Katrina B. Mar
title	LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
title_short	LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
title_full	LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
title_fullStr	LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
title_full_unstemmed	LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
title_sort	ly6e mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/32b1f2d4d5494f82ad2fcf71b16e8791
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LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

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