Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

Nanoparticles can stimulate tumour microenvironment to promote anti-tumour immunity. Here, the authors show that the combination of delivering drugs by a nanoscale coordination polymer and anti-PD-L1 is synergistic in treating murine colorectal cancer.

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Autores principales: Xiaopin Duan, Christina Chan, Wenbo Han, Nining Guo, Ralph R. Weichselbaum, Wenbin Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/32d406d04174474cb36aa4ac0dbdafaa
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spelling oai:doaj.org-article:32d406d04174474cb36aa4ac0dbdafaa2021-12-02T14:40:18ZImmunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors10.1038/s41467-019-09221-x2041-1723https://doaj.org/article/32d406d04174474cb36aa4ac0dbdafaa2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09221-xhttps://doaj.org/toc/2041-1723Nanoparticles can stimulate tumour microenvironment to promote anti-tumour immunity. Here, the authors show that the combination of delivering drugs by a nanoscale coordination polymer and anti-PD-L1 is synergistic in treating murine colorectal cancer.Xiaopin DuanChristina ChanWenbo HanNining GuoRalph R. WeichselbaumWenbin LinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaopin Duan
Christina Chan
Wenbo Han
Nining Guo
Ralph R. Weichselbaum
Wenbin Lin
Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
description Nanoparticles can stimulate tumour microenvironment to promote anti-tumour immunity. Here, the authors show that the combination of delivering drugs by a nanoscale coordination polymer and anti-PD-L1 is synergistic in treating murine colorectal cancer.
format article
author Xiaopin Duan
Christina Chan
Wenbo Han
Nining Guo
Ralph R. Weichselbaum
Wenbin Lin
author_facet Xiaopin Duan
Christina Chan
Wenbo Han
Nining Guo
Ralph R. Weichselbaum
Wenbin Lin
author_sort Xiaopin Duan
title Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
title_short Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
title_full Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
title_fullStr Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
title_full_unstemmed Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
title_sort immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/32d406d04174474cb36aa4ac0dbdafaa
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AT christinachan immunostimulatorynanomedicinessynergizewithcheckpointblockadeimmunotherapytoeradicatecolorectaltumors
AT wenbohan immunostimulatorynanomedicinessynergizewithcheckpointblockadeimmunotherapytoeradicatecolorectaltumors
AT niningguo immunostimulatorynanomedicinessynergizewithcheckpointblockadeimmunotherapytoeradicatecolorectaltumors
AT ralphrweichselbaum immunostimulatorynanomedicinessynergizewithcheckpointblockadeimmunotherapytoeradicatecolorectaltumors
AT wenbinlin immunostimulatorynanomedicinessynergizewithcheckpointblockadeimmunotherapytoeradicatecolorectaltumors
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