Sensing and responding to allergic response cytokines through a genetically encoded circuit

The standard treatment for an allergic response is anti-histamines, steroids and anti-IgE antibodies. Here the authors present a genetic circuit that senses IL-4 and IL-13 and responses with DARPin production to bind IgE.

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Detalles Bibliográficos
Autores principales: Hélène Chassin, Barbara Geering, Lina Schukur, David Ausländer, Brian Lang, Martin Fussenegger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/33084c3c97df4da3aeedbbb2271d4033
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Descripción
Sumario:The standard treatment for an allergic response is anti-histamines, steroids and anti-IgE antibodies. Here the authors present a genetic circuit that senses IL-4 and IL-13 and responses with DARPin production to bind IgE.