Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.

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Autores principales: Søs Grønbæk Holdgaard, Valentina Cianfanelli, Emanuela Pupo, Matteo Lambrughi, Michal Lubas, Julie C. Nielsen, Susana Eibes, Emiliano Maiani, Lea M. Harder, Nicole Wesch, Mads Møller Foged, Kenji Maeda, Francesca Nazio, Laura R. de la Ballina, Volker Dötsch, Andreas Brech, Lisa B. Frankel, Marja Jäättelä, Franco Locatelli, Marin Barisic, Jens S. Andersen, Simon Bekker-Jensen, Anders H. Lund, Vladimir V. Rogov, Elena Papaleo, Letizia Lanzetti, Daniela De Zio, Francesco Cecconi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/332640b7f2f048bebeba04c9ee651443
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https://doaj.org/article/332640b7f2f048bebeba04c9ee651443

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