Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.
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Nature Portfolio
2019
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oai:doaj.org-article:332640b7f2f048bebeba04c9ee6514432021-12-02T16:51:00ZSelective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites10.1038/s41467-019-12094-92041-1723https://doaj.org/article/332640b7f2f048bebeba04c9ee6514432019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12094-9https://doaj.org/toc/2041-1723Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.Søs Grønbæk HoldgaardValentina CianfanelliEmanuela PupoMatteo LambrughiMichal LubasJulie C. NielsenSusana EibesEmiliano MaianiLea M. HarderNicole WeschMads Møller FogedKenji MaedaFrancesca NazioLaura R. de la BallinaVolker DötschAndreas BrechLisa B. FrankelMarja JäätteläFranco LocatelliMarin BarisicJens S. AndersenSimon Bekker-JensenAnders H. LundVladimir V. RogovElena PapaleoLetizia LanzettiDaniela De ZioFrancesco CecconiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Søs Grønbæk Holdgaard Valentina Cianfanelli Emanuela Pupo Matteo Lambrughi Michal Lubas Julie C. Nielsen Susana Eibes Emiliano Maiani Lea M. Harder Nicole Wesch Mads Møller Foged Kenji Maeda Francesca Nazio Laura R. de la Ballina Volker Dötsch Andreas Brech Lisa B. Frankel Marja Jäättelä Franco Locatelli Marin Barisic Jens S. Andersen Simon Bekker-Jensen Anders H. Lund Vladimir V. Rogov Elena Papaleo Letizia Lanzetti Daniela De Zio Francesco Cecconi Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| description |
Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity. |
| format |
article |
| author |
Søs Grønbæk Holdgaard Valentina Cianfanelli Emanuela Pupo Matteo Lambrughi Michal Lubas Julie C. Nielsen Susana Eibes Emiliano Maiani Lea M. Harder Nicole Wesch Mads Møller Foged Kenji Maeda Francesca Nazio Laura R. de la Ballina Volker Dötsch Andreas Brech Lisa B. Frankel Marja Jäättelä Franco Locatelli Marin Barisic Jens S. Andersen Simon Bekker-Jensen Anders H. Lund Vladimir V. Rogov Elena Papaleo Letizia Lanzetti Daniela De Zio Francesco Cecconi |
| author_facet |
Søs Grønbæk Holdgaard Valentina Cianfanelli Emanuela Pupo Matteo Lambrughi Michal Lubas Julie C. Nielsen Susana Eibes Emiliano Maiani Lea M. Harder Nicole Wesch Mads Møller Foged Kenji Maeda Francesca Nazio Laura R. de la Ballina Volker Dötsch Andreas Brech Lisa B. Frankel Marja Jäättelä Franco Locatelli Marin Barisic Jens S. Andersen Simon Bekker-Jensen Anders H. Lund Vladimir V. Rogov Elena Papaleo Letizia Lanzetti Daniela De Zio Francesco Cecconi |
| author_sort |
Søs Grønbæk Holdgaard |
| title |
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| title_short |
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| title_full |
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| title_fullStr |
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| title_full_unstemmed |
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| title_sort |
selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/332640b7f2f048bebeba04c9ee651443 |
| work_keys_str_mv |
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