Structure of human Cdc45 and implications for CMG helicase function

The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.

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Autores principales: Aline C. Simon, Vincenzo Sannino, Vincenzo Costanzo, Luca Pellegrini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/336a490581984f819349c8beafd6bee9
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