Structure of human Cdc45 and implications for CMG helicase function

The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.

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Autores principales:	Aline C. Simon, Vincenzo Sannino, Vincenzo Costanzo, Luca Pellegrini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/336a490581984f819349c8beafd6bee9
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spelling	oai:doaj.org-article:336a490581984f819349c8beafd6bee92021-12-02T14:39:30ZStructure of human Cdc45 and implications for CMG helicase function10.1038/ncomms116382041-1723https://doaj.org/article/336a490581984f819349c8beafd6bee92016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11638https://doaj.org/toc/2041-1723The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.Aline C. SimonVincenzo SanninoVincenzo CostanzoLuca PellegriniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aline C. Simon Vincenzo Sannino Vincenzo Costanzo Luca Pellegrini Structure of human Cdc45 and implications for CMG helicase function
description	The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.
format	article
author	Aline C. Simon Vincenzo Sannino Vincenzo Costanzo Luca Pellegrini
author_facet	Aline C. Simon Vincenzo Sannino Vincenzo Costanzo Luca Pellegrini
author_sort	Aline C. Simon
title	Structure of human Cdc45 and implications for CMG helicase function
title_short	Structure of human Cdc45 and implications for CMG helicase function
title_full	Structure of human Cdc45 and implications for CMG helicase function
title_fullStr	Structure of human Cdc45 and implications for CMG helicase function
title_full_unstemmed	Structure of human Cdc45 and implications for CMG helicase function
title_sort	structure of human cdc45 and implications for cmg helicase function
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/336a490581984f819349c8beafd6bee9
work_keys_str_mv	AT alinecsimon structureofhumancdc45andimplicationsforcmghelicasefunction AT vincenzosannino structureofhumancdc45andimplicationsforcmghelicasefunction AT vincenzocostanzo structureofhumancdc45andimplicationsforcmghelicasefunction AT lucapellegrini structureofhumancdc45andimplicationsforcmghelicasefunction
_version_	1718390584271437824

Structure of human Cdc45 and implications for CMG helicase function

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