Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

The cause of clonal expansions in the HIV reservoir remains unclear. Here, Gantner et al. perform single-cell TCR sequencing on longitudinal samples from eight individuals on antiretroviral therapy and find that antigens inducing clonal expansions of memory cells are major contributors to the HIV re...

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Autores principales:	Pierre Gantner, Amélie Pagliuzza, Marion Pardons, Moti Ramgopal, Jean-Pierre Routy, Rémi Fromentin, Nicolas Chomont
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3373c5bb985147038f60f26d612194f7
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spelling	oai:doaj.org-article:3373c5bb985147038f60f26d612194f72021-12-02T19:06:29ZSingle-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART10.1038/s41467-020-17898-82041-1723https://doaj.org/article/3373c5bb985147038f60f26d612194f72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17898-8https://doaj.org/toc/2041-1723The cause of clonal expansions in the HIV reservoir remains unclear. Here, Gantner et al. perform single-cell TCR sequencing on longitudinal samples from eight individuals on antiretroviral therapy and find that antigens inducing clonal expansions of memory cells are major contributors to the HIV reservoir.Pierre GantnerAmélie PagliuzzaMarion PardonsMoti RamgopalJean-Pierre RoutyRémi FromentinNicolas ChomontNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Gantner Amélie Pagliuzza Marion Pardons Moti Ramgopal Jean-Pierre Routy Rémi Fromentin Nicolas Chomont Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
description	The cause of clonal expansions in the HIV reservoir remains unclear. Here, Gantner et al. perform single-cell TCR sequencing on longitudinal samples from eight individuals on antiretroviral therapy and find that antigens inducing clonal expansions of memory cells are major contributors to the HIV reservoir.
format	article
author	Pierre Gantner Amélie Pagliuzza Marion Pardons Moti Ramgopal Jean-Pierre Routy Rémi Fromentin Nicolas Chomont
author_facet	Pierre Gantner Amélie Pagliuzza Marion Pardons Moti Ramgopal Jean-Pierre Routy Rémi Fromentin Nicolas Chomont
author_sort	Pierre Gantner
title	Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
title_short	Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
title_full	Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
title_fullStr	Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
title_full_unstemmed	Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
title_sort	single-cell tcr sequencing reveals phenotypically diverse clonally expanded cells harboring inducible hiv proviruses during art
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3373c5bb985147038f60f26d612194f7
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Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

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