Quantitative modelling of amino acid transport and homeostasis in mammalian cells

Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.

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Auteurs principaux: Gregory Gauthier-Coles, Jade Vennitti, Zhiduo Zhang, William C. Comb, Shuran Xing, Kiran Javed, Angelika Bröer, Stefan Bröer
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf7097
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